![]() An extensive protocol over 5 days was applied to determine precision, accuracy and trueness. ![]() Selectivity and specificity were assessed using spiked serum potential matrix effects were examined by a post column infusion experiment and the comparison of standard line slopes. Assay validation was performed according to current guidelines. For liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis a two-dimensional heart cut LC approach, in combination with an optimal supported liquid extraction protocol, was established for the accurate analysis of aldosterone in human serum and plasma in order to minimize matrix effects and avoid the co-elution of interferences. Methods The material used in this RMP was characterized by quantitative nuclear magnetic resonance (qNMR) to assure traceability to SI Units. Objectives An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC MS/MS)-based candidate reference measurement procedure (RMP) for aldosterone quantification in human serum and plasma is presented. Results must be shared in a transparent manner to allow other stakeholders including NMIs to reproduce and disseminate the reference measurement procedures. Both for RMPs and CRMs Joint Committee for Traceability in Laboratory Medicine (JCTLM) listing must be the ultimate goal. Certified reference material (CRM) characterization must be thorough, e.g., by the application of quantitative nuclear magnetic resonance measurements and by adherence to ISO 15194. Adherence to International Organization for Standardization (ISO) procedure 15193 must be a matter of course for the establishment of reference measurement procedures (RMPs). Traceability initiatives established by in vitro device industry or academia must meet the quality standards of NMIs. If NMIs are not in the position to take up this task, alternative approaches must be sought. The establishment of traceability chains must be initiated by National Metrology Institutes (NMIs) according to applicable standards they are at the top and leading position in this concept. Web of Science - Science Citation Index Expandedįor molecules that can be well described metrologically in the sense of the definition of measurands, and which can also be recorded analytically as individual substances, reference measurement service traceability to a metrologically sound foundation is a necessity.Web of Science - Science Citation Index.Web of Science - Prous Science Integrity.Web of Science - Current Contents/Life Sciences.Ulrich's Periodicals Directory/ulrichsweb.Norwegian Register for Scientific Journals, Series and Publishers.KESLI-NDSL (Korean National Discovery for Science Leaders).Journal Citation Reports/Science Edition.Japan Science and Technology Agency (JST).CNKI Scholar (China National Knowledge Infrastructure).Chemical Abstracts Service (CAS) - SciFinder.Chemical Abstracts Service (CAS) - CAplus.Click on the section “International Journals” on the left-hand side where you find CCLM as the first listed journal.Ĭlinical Chemistry and Laboratory Medicine (CCLM) is covered by the following services: To take advantage of all the opportunities offered to members of the EFLM Academy, please access your personal area in the EFLM Academy at the link (if you do not remember your login details, you can use the option FORGOT PASSWORD). Research Articles, Reviews, Mini Reviews and Opinion Papers on all aspects of clinical chemistry and laboratory medicine, Guidelines and Recommendations, Point/Counterpoint Articles, Letters to the Editor, Editorials quality and safety in laboratory medicine.new reagents, instrumentation and technologies.disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes).clinical genomics and molecular biology.Letters to the Editor and Congress Abstracts are published online only. It is issued monthly, both in print and electronically. CCLM is led by a multi-institutional editorial board. All contributions submitted for publication in CCLM are single-blind peer reviewed by at least two experts in the field. CCLM is one of the leading journals in the field, with an impact factor over 8. It is focused on basic and applied research and cutting-edge clinical laboratory medicine. Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine.
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